Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test

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Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test.

We investigated the role of sensory nerves in glucose tolerance in conscious Wistar rats neonatally treated with neurotoxin capsaicin or vehicle. Intravenous glucose tolerance tests (IVGTT, 150, 300 and 450 mg in 30 min) were performed to measure glucose tolerance, and glucose, insulin and glucagon levels were measured. Higher glucose concentration resulted in a greater insulin response in both...

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Capsaicin-Sensitive Afferent Nerves and the Human Gastrointestinal Tract

Capsaicin activates the capsaicin (vanilloid) receptor expressed a subgroup of primary afferent nociceptive neurons (Szolcsányi, 2004). The capsaicin receptor has been cloned (Caterina et al., 1997) and turned out to be a cation channel. It is gated besides capsaicin and other capsaicinoids (some vanilloids) by low pH, noxious heat and various pains – producing endogenous and exogenous chemical...

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Multiscale modelling of insulin secretion during an intravenous glucose tolerance test.

Dysfunctional insulin secretion from pancreatic β-cells plays a major role in the development of diabetes. The intravenous glucose tolerance test (IVGTT) is a widely used clinical test to assess β-cell function. The analysis of IVGTT data is conveniently performed using mathematical models, which need to be fairly simple to enable parameter identifiability (minimal models), but should at the sa...

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A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin.

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ژورنال

عنوان ژورنال: Life Sciences

سال: 2005

ISSN: 0024-3205

DOI: 10.1016/j.lfs.2005.03.011